Two-Component Signaling System Inhibition of Competence by the CiaRH Pneumococcal HtrA Protease Mediates
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Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system.
Activation of the CiaRH two-component signaling system prevents the development of competence for genetic transformation in Streptococcus pneumoniae through a previously unknown mechanism. Earlier studies have shown that CiaRH controls the expression of htrA, which we show encodes a surface-expressed serine protease. We found that mutagenesis of the putative catalytic serine of HtrA, while not ...
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UNLABELLED Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation but also the production of cellular chaperones and proteases. We have shown he...
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تاریخ انتشار 2004